Abstract
6-Nitroquipazine has been known as one of the most potent and selective inhibitors of serotonin transporter in vitro and in vivo. Nine derivatives of 6-nitroquipazine were synthesized and tested for their potential abilities to displace [3H]citalopram binding to the rat cortical membranes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding, Competitive
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Carrier Proteins / metabolism*
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Cell Membrane / metabolism
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Cerebral Cortex / metabolism
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Citalopram / pharmacokinetics
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Drug Design
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Indicators and Reagents
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Kinetics
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Membrane Glycoproteins / metabolism*
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Membrane Transport Proteins*
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Models, Structural
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Molecular Conformation
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Nerve Tissue Proteins*
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Quipazine / analogs & derivatives*
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Quipazine / chemical synthesis*
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Quipazine / chemistry
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Quipazine / pharmacokinetics
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Quipazine / pharmacology
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Rats
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Selective Serotonin Reuptake Inhibitors / chemical synthesis
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Selective Serotonin Reuptake Inhibitors / chemistry
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Selective Serotonin Reuptake Inhibitors / pharmacokinetics
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Serotonin Plasma Membrane Transport Proteins
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Structure-Activity Relationship
Substances
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Carrier Proteins
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Indicators and Reagents
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Serotonin Plasma Membrane Transport Proteins
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Serotonin Uptake Inhibitors
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Slc6a4 protein, rat
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Citalopram
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Quipazine
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6-nitroquipazine